MR Enterography is a magnetic resonance imaging technique used to evaluate bowel wall features of both upper and lower gastro-intestinal tract, although it's usually used for small bowel evaluation. It is a less invasive technique with the advantages of no ionizing radiation exposure, multiplanarity and high contrast resolution for soft tissue.
The term MR enterography and MR enteroclisys are similar, but the first is referred to a MR exam with orally administered enteric contrast media, and the second to a more invasive technique in which enteric contrast media is administered through the fluoroscopy-guided positioned naso-jejuneal tube.
The need for imaging assessment of small bowel diseases comes from the limits of traditional endoscopy in evaluating Ileum loops - even modern capsule endoscopy is not routinely performed as barely available. Over the past several years assessment of small bowel diseases was performed by Barium follow through, or upper and lower gastrointestinal series, that provided plan film of bowel loop lumen, thanks to the swallowing or instillation of radiopaque agents mixed with water or other neutral contrast media. Gastrointestinal series allow to depict lumen caliber, gross mucosal alterations and wide fistulous tract, but were poorly diagnostic for submucosal or extraluminal features. CT scan instead provides cross sectional and multiplanar images of intraluminal and extra-mucosal, extra-luminal or even extra-enteric features, but costing higher radiation dose.
The spread of MR technic has revolutionized the diagnostic imaging of the small bowel loop, restricting CT scan to particular situations, such as emergency or MR contraindications like patients with pacemaker implant, recently implanted vascular/bilious stent or other ferromagnetic prosthesis/devices. It is a safe, multi-planar imaging modality with high soft tissue contrast resolution that does not expose to ionizing radiation, so it's feasible for young patients or when several follow up are required.
Video MR Enterography
Preparation
Cathartic preparation should be performed in order to clean bowel loops from stool residuals and allow a better visualization of mucosal features and an easier luminal distention as well. It usually implies a fiber restriction diet and intake of water solution with laxative effect few days before the exam, and abstaining from food intake starting from 6 hours prior to the study.
Use of Enteric contrast media is recommended, aiming to distend small bowel loops, and it's administered orally at regular intervals approximately 40 minutes before the study.
The type of endo-luminal contrast media varies among negative contrast media, consisting of superparamagnetic agents that evoke low signal both in T1 and T2 weighted images, positive contrast media, represented by paramagnetic agents, that produce high signal on both sequences, or biphasic contrast media, that gives high signal intensity in T2 and low intensity in T1. This latter, that consists of water, methyl cellulose or polyethylene glycol, is the most used, because of the wide availability, low cost, good patient compliance and good taste. Water enema may be administered as well in order to distend bowel loop (MR-colonography).
Intravenous contrast media increases diagnostic capability of Enterography MRI. Although it's better tolerated than iodinated contrast media used for CT-scan, the use of Gadolinium-based contrast agent should always be preceded by kidney function assessment, in order to reduce the risk of systemic nephrogenic sclerosis, and prophylactic protocol in case of previous allergic reactions.
Spasmolityc agents may be used to reduce the motion artifacts due to peristalsis.
Maps MR Enterography
Protocol
High field MR scanners and the use of multi-channel phased array surface coil are suggested in order to obtain adequately diagnostic images.
The patient is placed in prone position, thus provides better separation of bowel loops and reduces breathing movement-artifacts. Although MR Enterography protocols may vary among different hospital/institutions, the main sequences are the following:
Axial and Coronal balanced Steady State Free precession
Axial and Coronal Single-shot-FSE with fat saturation
Axial and Coronal 3D spoiled GE before and after contrast media administration
Axial DWI sequences, using at least 2 B-value.
Cine loop technic using SSFP sequences
Indications
The most common indication of MR enterography is diagnosis and follow up of inflammatory and neoplastic small bowel disease
Risks and contraindications
Risks and contraindications are the same of any MR exam.
References
Fidler JL, Guimaraes L, Einstein DM. MR Imaging of the Small Bowel. RadioGraphics 2009; 29:1811-1825
Ilangovan R, Burling D, George A, Gupta A, Marshall M, and Taylor SA. CT enterography: review of technique and practical tips. Br J Radiol. 2012 Jul; 85(1015): 876-886
Lo Re G, Midiri M, et Al. Crohn's disease. Radiological features and clinical-surgical correlations; Cap.12:107-113; Cap.14:128-133
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