Clobetasol propionate is a corticosteroid of the glucocorticoid class used to treat various skin disorders including eczema and psoriasis. It is also very effective for contact dermatitis caused by exposure to poison ivy/oak. Clobetasol belongs to US Class I (European: class IV) of corticosteroids, making it one of the most potent available. It came in shampoo, mousse, ointment and emollient cream presentation. It has very high potential and usually should not be used with occlusive dressing, or for continuous continuous use (beyond two weeks). It is also used to treat some autoimmune diseases including alopecia areata, lichen sclerosus, and lichen planus.
Video Clobetasol propionate
Usage
Clobetasol propionate is used for the treatment of various skin disorders including eczema, herpes labialis, psoriasis, and lichen sclerosus. It is also used to treat some auto-immune diseases including alopecia areata, lichen planus (auto immune skin nodules), and mycosis fungoides (T-cell lymphoma). It is used as first-line treatment for acute and chronic GVHD of the skin.
Clobetasol proprionate is used cosmetically by dark-skinned women to whiten skin, although this use is controversial. The US Food and Drug Administration has not yet agreed for that purpose, and non-prescription selling is illegal in the US However, skin-whitening creams containing this ingredient can sometimes be found in ethnic beauty shops in New York City and on the internet.. It is also sold internationally, and does not require recipes in some countries. Bleaching cream with clobetasol proprionate, like Hyprogel, can make skin thin and bruised easily, with visible capillaries, and pimples. It can also cause hypertension, increased blood sugar, natural steroid suppression of the body, and stretch marks, which may be permanent.
Clobetasol propionate is, along with mercury and hydroquinone, "among the most toxic and most frequently used agents in lightening products." Many products sold illegally have higher concentrations of klobetasol propionate than are allowed for prescription drugs.
Maps Clobetasol propionate
Contraindications
According to the California Environmental Protection Agency, clobetasol propionate should not be used by pregnant women, or women who hope to get pregnant soon, because studies with mice indicate the risk of birth defects:
"Studies in mice after oral administration at dose levels up to 50 mcg/kg per day showed that women showed an increase in the number of embryos being resorbed and a decrease in the number of live fetuses at the highest doses Pregnancy: Teratogenic effects (ie, possibly causing abnormalities in the fetus): Category Pregnancy C: Clobetasol propionate has not been tested for teratogenicity when applied topically but is percutaneously absorbed, and when given subcutaneously it is significant teratogens in both rabbits and mice Clobetasol propionate has greater teratogenic potential than less potent steroids. adequate and well-controlled studies of the teratogenic effects of clobetasol propionate in pregnant women.Temovate Cream and Ointment should be used during pregnancy only if potential benefits justify the potential risks to the fetus. "
Form
Clobetasol propionate is marketed and sold worldwide with various names including Clobex , Clob-x (Colombia), Clovate , Clonovate (Halogen) (Switzerland, by ELKO Org), Pentasol (Colombia) (For Chemistry, Thailand), Cormax (Watson, , Cosvate, Clop (Cadila Healthcare, India), Propisalic (India), Temovate (USA), Dermovate (GlaxoSmithKline, Canada, Pakistan, Portugal, Israel), Olux , ClobaDerm , Tenovate , Dermatovate , Butavate , Movate , Novate , Salac (Argentina), and Powercort .
See also
- Desoximetasone
References
Source of the article : Wikipedia
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