Etodolac

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Etodolac is a nonsteroidal anti-inflammatory drug (NSAID) approved by the US Food and Drug Administration in January 1991.

By 2015, the cost for one month of treatment in the United States is less than 25 USD.

Video Etodolac

Medical use

NSAIDs are used for mild to moderate pain management, fever, and inflammation. They work by reducing the level of prostaglandins, which are chemicals responsible for the pain and fever and tenderness that occur with inflammation. Etodolac blocks the enzyme cyclooxygenase (abbreviation of COX) that forms the prostanoid, resulting in lower prostaglandin concentrations. As a result, inflammation, pain and fever are reduced.

Post-marketing studies show that etodolac inhibition of cyclooxygenase is somewhat COX-2 selectively similar to celecoxib and other "COX-2 inhibitors". Unlike rofecoxib, both etodolac and celecoxib can completely inhibit COX-1 and are defined as having "preferential selectivity" against COX-2. The R-enantiomer etodolac is not active against COX enzymes, but inhibits beta-catenin levels in hepatoma cells.

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Indication

Etodolac is licensed for the treatment of inflammation and pain caused by osteoarthritis and rheumatoid arthritis.

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Interactions

Etodolac should be avoided by patients with a history of asthma attacks, rashes, or other allergic reactions to aspirin or other NSAIDs. Rare but severe allergic reactions have been reported in such individuals. It should also be avoided by patients with peptic ulcer disease or poor kidney function, as this drug may aggravate both conditions. Etodolac is used with caution in patients taking blood-thinning drugs (anticoagulants), such as warfarin (Coumadin), as it increases the risk of bleeding. Patients taking lithium and etodolac may develop lithium levels in toxic blood. In addition, etodolac has been found to interact with certain anti-depressant drugs, such as sertraline or fluoxetine, which can increase the risk of stroke, heart attack, and other cardiovascular conditions. Patients also taking ciclosporin (Sandimmune) may develop renal toxicity. Use in children has not been adequately studied. Etodolac is not a habit-maker. NSAIDs must be discontinued prior to elective surgery due to mild interference with clots that are characteristic of this group of drugs. Etodolac is best stopped at least four days before surgery. Metabolism of etodolac may also cause false-positive bilirubin results in urinalysis tests. [1]

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Pregnancy and breast-feeding

Etodolac is generally avoided during pregnancy and lactation. NSAIDs can cause adverse cardiovascular effects on the fetus during pregnancy.

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Brand name

Etodolac is manufactured by Almirall Limited under the trade name Lodine SR and by Meda Pharmaceuticals under the name Eccoxolac . Generic etodolac is also available.

The drug is also sold under several other brand names, including:

• "Etogesic" (India)
• Etova (India)
• Dualgan (Portugal)
• Etodin (South Korea)
• Etofree (India)
• Etopant (Israel)
• Flancox Ã,® (Brazil)
• Haipen (Japan)
• Lodine (France, Switzerland, United States)
• Proxym (S Etodolac) (India)
• Ethol (Turkey)
• Lonine (Taiwan)
• Etodine (Egypt)
• Dolarit (Turkish)
• "Etodin Fort" (Bulgaria)

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References

src: pillbox.nlm.nih.gov

External links

• DrugBank Info
• Medicinenet.com

Source of the article : Wikipedia