The drug combination bismuth subcitrate/metronidazole/tetracycline (trade name Pylera ) is used for the treatment of peptic ulcer with infection by bacterium Helicobacter pylori .
Video Bismuth subcitrate/metronidazole/tetracycline
Medical use
This combination is used in conjunction with omeprazole as 'quadruple therapy' for the eradication of H. pylori and to prevent peptic ulcers caused by this bacteria.
Maps Bismuth subcitrate/metronidazole/tetracycline
Contraindications
Drugs should not be taken by pregnant women, because tetracycline is known to cause tooth and bone damage in unborn children. It is also contraindicated in lactating women, children up to age 12, and by patients with impaired renal or kidney function, as no research on such people is performed. Tetracycline also tends to be harmful in liver patients.
Adverse effects
Common side effects include diarrhea, nausea and dysgeusia (taste sense distortion), especially metal flavor. This effect is known from the drug component as well as from other antibiotics. A very rare but dangerous reaction is the Stevens-Johnson syndrome, a life-threatening condition that affects the skin, which has also been described under metronidazole and tetracycline as a separate drug.
Interactions
Metronidazole in combination with alcohol causes severe reactions such as vomiting and flushes in many patients. The tetracycline resorption is reduced by dairy products, antacids and other products containing calcium, magnesium, aluminum and iron.
Action mechanism
Chemical properties
Bismuth subcitrate potassium is bismuth salt, potasium (K ) and citrate (C 6 7 3 - ), containing about 25.6% (percent mass) of bismuth, which is the active part, and 22.9% potassium. Tetracycline is contained as hydrochloride, and metronidazole as pure substance.
References
Source of the article : Wikipedia
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