Forced degradation or accelerated degradation is a process in which the natural degradation rate of a product or material increases with the application of additional pressure.
Video Forced degradation
Introduction
Forced degradation studies are used to identify possible reactions to decrease the processed product. Usually performed before the final formulation, forced degradation uses external pressure to rapidly filter material stability.
Long-term storage tests are usually used to measure similar properties when the final formulation is involved because of strict FDA regulations. These tests are generally more expensive (due to time involved) than forced degradation which is therefore used for quick selection and elimination tests.
Maps Forced degradation
General pressures
There are a number of common pressures used for it
- pH (acid/base)
Chemical processes are often catalyzed by the presence of acids and bases. The exposure of these materials can therefore accelerate the degradation reaction.
- Temperature
In accordance with the kinetics of arrhenius, an increase in temperature increases the rate of degradation process. Temperature is often used in conjunction with other pressures to increase the reaction rate.
- Oxidation
- Concentration
- Light
Methodology
Standard methodologies include:
- Wet chemical method
- Chemical flow
- Calor
Apps
To demonstrate the specificity when developing stability indicates method. To help identify the reactions that lead to degradation of pharmaceutical products. As part of strategy development method. Designed to produce product related variants.
See also
- Chemical decomposition
- Thermogravimetric analysis
- Total productive care
External links
- Chemical degradation flow by Syrris
Source of the article : Wikipedia
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