Phosphate binder is a drug used to reduce phosphate absorption and taken with food and snacks. They are usually used in people with chronic renal failure (CKF) because they often have difficulty getting rid of phosphates that enter into their blood (ie, serum phosphate in chronic renal failure usually increases).
Video Phosphate binder
Medical use
For people with chronic renal failure, controlling serum phosphate is important because it deals with bone pathology and is regulated along with serum calcium by parathyroid hormone (PTH). [1]
They are also used in hypoparathyroidism that is present with hypocalcemia with hyperphosphatemia.
Maps Phosphate binder
Adverse effects
With respect to phosphate binders, aluminum-containing compounds (such as aluminum hydroxide) are the least preferred because prolonged aluminum intake may cause encephalopathy and osteomalacia. If calcium is already used as a supplement, the extra calcium used as a phosphate binder can cause hypercalcaemia and tissue-damaging calcinosis. One can avoid this adverse effect by using a phosphate binder that does not contain calcium or aluminum as an active ingredient, such as lanthanum carbonate or sevelamer.
Agent options
There are limited trials that compare phosphate binders with placebo in the treatment of hyperphosphatemia in people with chronic kidney disease. When compared to people who receive a calcium-based binder, people taking sevelamer have decreased all-cause mortality.
Type
- Calcium acetate/magnesium carbonate
Action mechanism
These drugs work by binding to the phosphate in the digestive tract, thus making it unavailable to the body for absorption. Therefore, these drugs are usually taken with food to bind any phosphate that may be present in the digested food. Phosphate binders may be simple molecular entities (such as magnesium, aluminum, calcium, or lanthanum salts) that react with phosphates and form insoluble compounds. Phosphate binders such as sevelamer can also be polymer structures bound to phosphates and then excreted.
References
Lederer E, Ouseph R, Erbeck K. Hyperphosphatemia, eMedicine.com, URL: http://www.emedicine.org/.com/med/topic1097.htm, Retrieved 14 July 2005.
External links
- High Phosphate Control - Fosrenol Official Site *
- Phosphate Binders: What Are They And How Does It Work? - American Renal Patient Association *
- Phosphate Binders - National Kidney Foundation
- Phosphate Binders - Northwest Kidney Center - a center providing services for people with ESRD in the Seattle area.
- High Phosphate - Phosphorus Control - Information for health care professionals on hyperphosphatemia care and management
General Phosphate Binder
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Hutchison, A. J.; Wilkie, M. (2012). "Use of magnesium as a drug in chronic kidney disease". Clinical Kidney Journal . 5 : i62. doi: 10.1093/ndtplus/sfr168. - Lanthanum - medlineplus.org
- Sevelamer - medlineplus.org
- Sevelamer - Renvela.com
Source of the article : Wikipedia
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